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| League History Index | Players | Teams | Managers | Leagues | Leaderboards | Awards | Accomplishments |
| Rank | Player | IP | YEAR | Open Career Leaderboard |
|---|---|---|---|---|
| 1 | Roger Clemens# | 281.0 | 1987 | |
| 2 | Randy Johnson# | 271.0 | 1999 | |
| 2 | Roger Clemens# | 271.0 | 1991 | |
| 4 | Curt Schilling# | 268.0 | 1998 | |
| 4 | Greg Maddux# | 268.0 | 1992 | |
| 6 | Greg Maddux# | 267.0 | 1993 | |
| 7 | Pat Hentgen# | 265.0 | 1996 | |
| 7 | Kevin Brown# | 265.0 | 1992 | |
| 9 | Roger Clemens# | 264.0 | 1988 | |
| 9 | Roger Clemens# | 264.0 | 1997 | |
| 9 | Pat Hentgen# | 264.0 | 1997 | |
| 12 | Greg Maddux# | 263.0 | 1991 | |
| 13 | Jose Rijo# | 257.0 | 1993 | |
| 13 | Kevin Brown# | 257.0 | 1998 | |
| 15 | Curt Schilling# | 256.0 | 2001 | |
| 15 | John Smoltz# | 256.0 | 1997 | |
| 17 | Darryl Kile# | 255.0 | 1997 | |
| 17 | Randy Johnson# | 255.0 | 1993 | |
| 19 | Curt Schilling# | 254.0 | 1997 | |
| 19 | Roger Clemens# | 254.0 | 1986 | |
| 21 | John Smoltz# | 253.0 | 1996 | |
| 21 | Roger Clemens# | 253.0 | 1989 | |
| 23 | Kevin Brown# | 252.0 | 1999 | |
| 23 | Charles Nagy# | 252.0 | 1992 | |
| 25 | Chuck Finley# | 251.0 | 1993 | |
| 25 | Scott Erickson# | 251.0 | 1998 | |
| 25 | Greg Maddux# | 251.0 | 1998 | |
| 25 | Jon Lieber# | 251.0 | 2000 | |
| 29 | Randy Johnson# | 249.0 | 2001 | |
| 29 | Greg Maddux# | 249.0 | 2000 | |
| 29 | Greg Maddux# | 249.0 | 1988 | |
| 32 | Randy Johnson# | 248.0 | 2000 | |
| 33 | John Smoltz# | 246.0 | 1992 | |
| 33 | Tom Glavine# | 246.0 | 1991 | |
| 33 | Roger Clemens# | 246.0 | 1992 | |
| 33 | Jose Lima# | 246.0 | 1999 | |
| 37 | Greg Maddux# | 245.0 | 1996 | |
| 38 | Randy Johnson# | 244.0 | 1998 | |
| 39 | John Smoltz# | 243.0 | 1993 | |
| 39 | Mike Mussina# | 243.0 | 1996 | |
| 41 | Roger Clemens# | 242.0 | 1996 | |
| 41 | Greg Swindell# | 242.0 | 1988 | |
| 43 | Pedro Martinez# | 241.0 | 1997 | |
| 43 | Mike Mussina# | 241.0 | 1992 | |
| 43 | Tom Glavine# | 241.0 | 2000 | |
| 46 | Andy Pettitte# | 240.0 | 1997 | |
| 46 | Tom Glavine# | 240.0 | 1997 | |
| 46 | Livan Hernandez# | 240.0 | 2000 | |
| 46 | Mike Morgan# | 240.0 | 1992 | |
| 50 | Brad Radke# | 239.0 | 1997 | |
| 50 | Tom Glavine# | 239.0 | 1993 | |
| 50 | Shane Reynolds# | 239.0 | 1996 | |
| 50 | Mike Hampton# | 239.0 | 1999 | |
| 54 | Kevin Appier# | 238.0 | 1993 | |
| 54 | Kenny Rogers# | 238.0 | 1998 | |
| 54 | Freddy Garcia# | 238.0 | 2001 | |
| 54 | Greg Maddux# | 238.0 | 1989 | |
| 54 | Greg Swindell# | 238.0 | 1991 | |
| 54 | Chuck Finley# | 238.0 | 1996 | |
| 60 | Mike Mussina# | 237.0 | 2000 | |
| 60 | Kevin Brown# | 237.0 | 1997 | |
| 60 | Greg Maddux# | 237.0 | 1990 | |
| 63 | Mike Morgan# | 236.0 | 1991 | |
| 63 | Chuck Finley# | 236.0 | 1990 | |
| 65 | Kevin Appier# | 235.0 | 1997 | |
| 65 | Tom Glavine# | 235.0 | 1996 | |
| 65 | Curt Schilling# | 235.0 | 1993 | |
| 65 | Tim Hudson# | 235.0 | 2001 | |
| 69 | Roger Clemens# | 234.0 | 1998 | |
| 69 | Livan Hernandez# | 234.0 | 1998 | |
| 69 | Jamie Moyer# | 234.0 | 1998 | |
| 69 | Jeff Fassero# | 234.0 | 1997 | |
| 69 | Tom Glavine# | 234.0 | 1999 | |
| 69 | Chan-ho Park# | 234.0 | 2001 | |
| 75 | Pedro Martinez# | 233.0 | 1998 | |
| 75 | Joe Mays# | 233.0 | 2001 | |
| 75 | Shane Reynolds# | 233.0 | 1998 | |
| 75 | Denny Neagle# | 233.0 | 1997 | |
| 75 | Jose Lima# | 233.0 | 1998 | |
| 75 | Kevin Brown# | 233.0 | 1996 | |
| 75 | Kevin Brown# | 233.0 | 1993 | |
| 75 | Greg Maddux# | 233.0 | 2001 | |
| 83 | Greg Maddux# | 232.0 | 1997 | |
| 83 | Darryl Kile# | 232.0 | 2000 | |
| 83 | Jon Lieber# | 232.0 | 2001 | |
| 83 | Steve Sparks# | 232.0 | 2001 | |
| 83 | Brad Radke# | 232.0 | 1996 | |
| 83 | Terry Mulholland# | 232.0 | 1991 | |
| 83 | Pedro Astacio# | 232.0 | 1999 | |
| 90 | Jeff Fassero# | 231.0 | 1996 | |
| 90 | Shane Reynolds# | 231.0 | 1999 | |
| 90 | David Wells# | 231.0 | 1999 | |
| 90 | John Burkett# | 231.0 | 1993 | |
| 90 | Andy Benes# | 231.0 | 1992 | |
| 90 | John Smoltz# | 231.0 | 1990 | |
| 90 | Andy Benes# | 231.0 | 1998 | |
| 97 | Andy Benes# | 230.0 | 1993 | |
| 97 | Andy Benes# | 230.0 | 1996 | |
| 97 | Scott Erickson# | 230.0 | 1999 | |
| 97 | Darryl Kile# | 230.0 | 1998 |
